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Open Access Case report

Tandospirone, a 5-HT1A partial agonist is effective in treating anorexia nervosa: a case series

Kyoji Okita1*, Akihiro Shiina12, Michiko Nakazato13 and Masaomi Iyo12

Author Affiliations

1 Department of Psychiatry, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba, 260-8677, Japan

2 Center for Forensic Mental Health, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba, 260–8670, Japan

3 Research Center for Child Mental Development, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba, 260-8670, Japan

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Annals of General Psychiatry 2013, 12:7  doi:10.1186/1744-859X-12-7

Published: 9 March 2013

Abstract

This case report details the therapeutic effects of tandospirone on two patients with anorexia nervosa, one with the restricting subtype (ANR), and another with the binge-eating/purging subtype (ANBP). A 22-year-old female patient with ANR and a 23-year-old female patient with ANBP were treated successfully with the 5-HT1A partial agonist tandospirone. After treatment, not only did both patients gain weight, they also showed improved scores on the Eating Disorder Examination Questionnaire. In addition, a 6-month follow-up showed maintenance of these effects. In this disorder, tandospirone may be an effective drug for long-term use with good patient compliance.

Keywords:
Anorexia nervosa; Pharmacotherapy; Treatment; Serotonin 1A receptor; Tandospirone