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This article is part of the supplement: International Society on Brain and Behaviour: 2nd International Congress on Brain and Behaviour

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Effect of cyproheptadine on combat related PTSD nightmares

Gholamhossien Ahmadzadeh*, Ghorbanali Asadolahi, Gavad Mahmodi and Arezoo Farhat

  • * Corresponding author: Gholamhossien Ahmadzadeh

Author Affiliations

Behavioral Science Research Center, Khorshid Medical Center Esfahan, Iran

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Annals of General Psychiatry 2006, 5(Suppl 1):S159  doi:10.1186/1744-859X-5-S1-S159

The electronic version of this article is the complete one and can be found online at:

Published:28 February 2006



Recent studies have shown the role serotonergic system in post-traumatic stress disorder. Trazodone and Nefazodone (5H2 antagonist) amilorated PTSD nightmares but the receptors are mixed. This study promoted an open trial of cyporoheptadine for Iran versus Iraq combat related PTSD patients nightmares.

Materials and methods

25 patients studies in 8 week, before after trial of cyproheptadine, the participant were male and chronic PTSD patients with combat related nightmares.


5 patients were excluded from the study because of side effects including dizziness and somnolence. 20 patients completed the study. Average nightmare severity decreased from 6.85 to 5.05 which was statistically signifcant (p < 0.01).


Cyproheptadine may be effective in PTSD nightmare treatment.


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