Table 1 |
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|
Common clinical presentations of the various types of frontotemporal dementia. |
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| Common Initial |
Behavioral Symptoms |
Cognitive Symptoms |
Commonly Affected |
|
|
|
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| Presentation |
Brain Region |
|||
| FvFTDa |
Personality |
Occur Early: |
Executive dysfunction |
Frontal/prefrontal |
| change |
Disinhibition |
Impaired working memory |
cortex |
|
| Impulsivity |
Perseveration |
Anterior temporal |
||
| Stereotypies |
Attentional deficits |
cortex |
||
| Apathy |
||||
| Hyperorality |
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| SDb |
Language |
Occur Early or Late: |
Fluent dysphasia |
Middle and inferior |
| abnormality |
Emotional distance |
Impaired semantic memory |
temporal neocortex |
|
| Interpersonal coldness |
Preserved autobiographical |
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| and working memory |
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| PAc |
Language |
Occur Late: |
Non-fluent/expressive |
Left perisylvian |
| abnormality |
May include any of the |
dysphasia |
cortex |
|
| above |
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|
a = Frontal variant frontotemporal dementia; b = Semantic dementia; c = Progressive aphasia | ||||
Weder et al. Annals of General Psychiatry 2007 6:15 doi:10.1186/1744-859X-6-15 |
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