Table 4

Effect of chronic dioscorea administration on the behavior of OVX rats in the EPM test


LA rats
 HA rats




0 mg/kg/day (n = 8)
 250 mg/kg/day (n = 10)
 750 mg/kg/day (n = 9)
 1 500 mg/kg/day (n = 7)
 0 mg/kg/day (n = 7)
 250 mg/kg/day (n = 8)
 750 mg/kg/day (n = 9)
 1 500 mg/kg/day (n = 10)
OAT
 Before
 59.3 ± 8.9
 50.6 ± 6.5
 57.5 ± 9.6
 59.6 ± 14.5
 5.1 ± 3.6
 6.0 ± 3.3
 6.5 ± 3.4
 3.9 ± 2.7

After
 32.3 ± 11.4
 23.2 ± 7.1 **
 49.6 ± 9.5
 37.6 ± 14.2
 10.8 ± 5.8
 17.2 ± 6.9
 33.5 ± 8.4 **
 21.3 ± 7.2 *
CAT
 Before
 205.5 ± 9.4
 220.8 ± 8.8
 209.3 ± 12.5
 206.6 ± 16.8
 277.0 ± 11.8
 269.2 ± 7.5
 261.8 ± 9.6
 276.3 ± 5.3

After
 228.3 ± 19.4
 247.0 ± 14.6
 211.1 ± 15.6
 224.2 ± 22.4
 264.2 ± 10.7
 264.9 ± 10.4
 239.3 ± 13.9 *
 239.6 ± 12.8 *
OAA
 Before
 8.0 ± 0.8
 5.2 ± 0.9
 9.7 ± 2.8
 8.0 ± 2.8
 0.6 ± 0.6
 0.8 ± 0.5
 0.9 ± 0.9
 0.4 ± 0.3

After
 6.3 ± 1.9
 2.8 ± 0.9 *
 7.6 ± 1.9
 5.4 ± 2.3
 1.1 ± 0.9
 2.5 ± 1.2
 3.9 ± 1.3 **
 1.8 ± 0.7
CAA
 Before
 21.8 ± 3.4
 19.5 ± 1.3
 24.0 ± 2.8
 21.3 ± 3.4
 27.1 ± 3.3
 23.1 ± 3.4
 28.4 ± 3.4
 28.5 ± 3.1

After
 20.5 ± 3.5
 22.1 ± 3.0
 21.3 ± 2.4
 21.1 ± 3.5
 20.6 ± 1.9
 18.1 ± 2.8
 19.9 ± 2.6 *
 24.9 ± 2.8
TAA
 Before
 29.8 ± 3.5
 24.7 ± 1.7
 33.7 ± 4.2
 29.3 ± 5.3
 27.7 ± 3.5
 23.9 ± 3.5
 29.3 ± 3.5
 28.9 ± 3.0

After
 26.8 ± 4.0
 24.9 ± 3.1
 28.9 ± 3.0
 26.6 ± 3.5
 21.7 ± 2.0
 20.6 ± 2.8
 23.8 ± 2.5
 26.7 ± 2.7

LA, low anxiety; HA, high anxiety; OAT, open arm time; CAT, enclosed arm time; OAA, open arm activity; CAA, enclosed arm activity; TAA, total arm activity. The data are expressed as the mean ± SEM. "Before" and "after" are the results for the EPM test before, and on day 23 of, dioscorea treatment. *, p < 0.05; **, p < 0.01, paired t-test, compared to the data before dioscorea treatment.

Ho et al. Annals of General Psychiatry 2007 6:21   doi:10.1186/1744-859X-6-21