Table 1 |
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|
Effect of ethanol pretreatment on bupropion HCI-induced convulsions: intensity of convulsions |
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| Dose (mg/kg), n = 10 per group |
Intensity of convulsions |
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|
|
||||||
| Mild |
Moderate |
Severe |
||||
|
|
||||||
| BUP |
ET + BUP |
BUP |
ET + BUP |
BUP |
ET + BUP |
|
|
|
||||||
| 0 (V or ET +V) |
0 |
1 |
0 |
1 |
0 |
0 |
| 100 |
1 |
37 |
1 |
65 |
0 |
7 |
| 110 |
21 |
10 |
1 |
5 |
0 |
0 |
| 120 |
19 |
17 |
2 |
4 |
0 |
0 |
|
n = 10 mice per group for bupropion HCl alone and ethanol + bupropion HCl treatment groups. BUP, bupropion HCl; ET, ethanol; V, vehicle or 0.9% sodium chloride (NaCl). | ||||||
Silverstone et al. Annals of General Psychiatry 2008 7:11 doi:10.1186/1744-859X-7-11 |
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