|
Effect of ethanol pretreatment on bupropion HCI-induced convulsions: percentage of convulsing mice |
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| Dose (mg/kg), n = 10 per group |
No. of convulsing mice |
Percentage of convulsing mice |
||
|
|
||||
| Bupropion HCl |
ET + Bupropion HCl |
Bupropion HCl |
ET + Bupropion HCl |
|
|
|
||||
| 0 (vehicle or ET+vehicle) |
0 |
1 |
0% |
10% |
| 100 |
2 |
7 |
20% |
70% |
| 110 |
3 |
7 |
30% |
70% |
| 120 |
6 |
7 |
60% |
70% |
|
n = 10 mice per group for bupropion HCl alone and ethanol + bupropion HCl treatment groups. ET, ethanol; vehicle, 0.9% sodium chloride (NaCl). | ||||
Silverstone et al. Annals of General Psychiatry 2008 7:11 doi:10.1186/1744-859X-7-11 |
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