|
Effect of ethanol pretreatment on bupropion HCI-induced convulsions: mean standard deviation (SD) convulsions per mouse |
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| Dose (mg/kg), n = 10 per group |
Total no. of convulsions |
Mean (SD) convulsions per mouse |
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|
|
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| BUP |
ET + BUP |
BUP |
ET + BUP |
p Value |
|
|
|
|||||
| 0 (V or ET +V) |
0 |
2 |
0.00 (0.00) |
0.20 (0.63) |
0.1027* |
| 100 |
2 |
109 |
0.20 (0.42) |
10.90 (7.28)† |
|
| 110 |
22 |
15 |
2.20 (4.49) |
1.50 (1.72) |
|
| 120 |
21 |
21 |
2.10 (1.97) |
2.10 (3.35) |
|
|
n = 10 mice per group for bupropion HCl alone and ethanol + bupropion HCl treatment groups. *p Value for overall ethanol-bupropion interaction effect (ethanol effect, overall p = 0.0183; bupropion dose effect, overall p = 0.0007). †p = 0.0019 for pairwise comparison with corresponding mean value for bupropion alone treatment. BUP, bupropion HCl; ET, ethanol; SD, standard deviation; V, vehicle or 0.9% sodium chloride (NaCl). | |||||
Silverstone et al. Annals of General Psychiatry 2008 7:11 doi:10.1186/1744-859X-7-11 |
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