|
Effect of ethanol pretreatment on bupropion HCI-induced convulsions: duration of convulsions |
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| Dose (mg/kg), n = 10 per group |
Duration of convulsions |
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|
|
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| No. of short convulsions (0 to 10 s) |
No. of medium convulsions (11 to 30 s) |
No. of long convulsions (≥ 31 s) |
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|
|
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| BUP |
ET + BUP |
BUP |
ET + BUP |
BUP |
ET + BUP |
|
|
|
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| 0 (V or ET +V) |
0 |
1 |
0 |
1 |
0 |
0 |
| 100 |
1 |
78 |
1 |
17 |
0 |
14 |
| 110 |
22 |
6 |
0 |
3 |
0 |
6 |
| 120 |
18 |
17 |
3 |
1 |
0 |
3 |
|
n = 10 mice per group for bupropion HCl alone and ethanol + bupropion HCl treatment groups. BUP, bupropion HCl; ET, ethanol; V, vehicle or 0.9% sodium chloride (NaCl). | ||||||
Silverstone et al. Annals of General Psychiatry 2008 7:11 doi:10.1186/1744-859X-7-11 |
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