Table 5 |
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|
Mean ± SD number of mild, moderate and severe convulsions following the intraperitoneal administration of bupropion HCl and bupropion metabolites |
||||||||||||
| Dose* (mg/kg) |
Bupropion HCl |
Erythrohydrobupropion HCl |
Threohydrobupropion HCl |
Hydroxybupropion HCl |
||||||||
|
|
||||||||||||
| Mild |
Moderate |
Severe |
Mild |
Moderate |
Severe |
Mild |
Moderate |
Severe |
Mild |
Moderate |
Severe |
|
|
|
||||||||||||
| 25 |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
| 50 |
- |
- |
- |
- |
0.1 ± 0.3 |
- |
5.4 ± 8.9 |
1.3 ± 1.5 |
0.3 ± 0.7 |
7.0 ± 7.5 |
2.4 ± 2.3 |
1.6 ± 3.7 |
| 75 |
0.5 ± 1.6 |
- |
- |
3.4 ± 5.4 |
1.8 ± 2.0 |
0.3 ± 0.5 |
10.8 ± 7.5 |
5.7 ± 5.5 |
4.7 ± 6.1 |
113.3 ± 110.1 |
20.7 ± 20.2 |
13.3 ± 17.8 |
|
*10 mice per dose per treatment. - Indicates no convulsions. | ||||||||||||
Silverstone et al. Annals of General Psychiatry 2008 7:19 doi:10.1186/1744-859X-7-19 |
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