Table 1 |
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|
Effect of bupropion HCl 120 mg/kg intraperitoneal infusion times on bupropion HCl-induced percentage of convulsing mice and on odds of convulsing vs not convulsing |
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| Group* |
Intraperitoneal (IP) infusion time (min) |
No. of mice convulsing |
Convulsing mice |
Reduction in odds of convulsing† |
|
|
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| 1 |
0 (bolus) |
6 |
60% |
- |
| 2 |
15 |
9 |
90% |
32.6% |
| 3 |
30 |
5 |
50% |
54.6% |
| 4 |
60 |
5 |
50% |
79.4% |
| 5 |
90 |
0 |
0% |
90.6% |
| 6 |
120 |
2 |
20% |
95.8% |
| 7 |
240 |
0 |
0% |
99.8% |
|
*Number of mice was 10 for each group, except group 5 that had 9 mice. †Reduced odds of convulsing vs not convulsing for any infusion time, x min, were calculated using the formula: 1 - (0.974x) × 100%; where 0.974 was the odds ratio estimate obtained from logistic regression analysis, and x = infusion time (min). | ||||
Silverstone et al. Annals of General Psychiatry 2008 7:27 doi:10.1186/1744-859X-7-27 |
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