Table 2 |
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Effect of bupropion HCl 120 mg/kg intraperitoneal infusion times on time to onset of bupropion HCl-induced convulsions and on odds of convulsing vs not convulsing in mice |
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| Group* |
Intraperitoneal (IP) infusion time (min) |
Time to Onset of Convulsions for Individual Mice (min)† |
Reduction in hazard (probability) of convulsing |
|
|
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| 1 |
0 (bolus) |
7; 30; 6; 120; 5; 11; 120; 120; 23; 120 |
- |
| 2 |
15 |
15; 120; 5; 18; 19; 23; 14; 20; 16; 13 |
28.4% |
| 3 |
30 |
20; 120; 17; 120; 120; 120; 120; 39; 42; 31 |
48.7% |
| 4 |
60 |
32; 120; 42; 120; 120; 60; 120; 70; 120; 69 |
73.7% |
| 5 |
90 |
120; 120; 120; 120; 120; 120; 120; 120; 120 |
86.5% |
| 6 |
120 |
120; 9; 41; 120; 120; 120; 120; 120; 120; 120 |
93.1% |
| 7 |
240 |
120; 120; 120; 120; 120; 120; 120; 120; 120; 120 |
99.5% |
|
*Number of mice was 10 for each group, except group 5 that had 9 mice. †Mice that did not have convulsions during treatment infusion and by the end of the 2-h post-treatment period were considered to be censored at 120 min. ‡Reduced hazard of convulsing vs not convulsing for any infusion time, x min, was calculated using the formula: 1 - (0.978x) × 100%; where 0.978 was the hazard ratio estimate obtained from Cox proportional hazards model, and x = infusion time (min). | |||
Silverstone et al. Annals of General Psychiatry 2008 7:27 doi:10.1186/1744-859X-7-27 |
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