Table 4 |
||||
|
Effect of bupropion HCl 120 mg/kg intraperitoneal infusion times on the mean ± SD duration of bupropion HCl-induced convulsions in mice |
||||
| Group* |
Intraperitoneal (IP) infusion time (min) |
Mean ± SD duration of convulsions |
||
| Short (0 to 10 s) |
Medium (11 to 30 s) |
Long (= 31 s) |
||
|
|
||||
| 1 |
0 (bolus) |
11.2 ± 15.6 |
2.6 ± 3.9 |
1.6 ± 4.4 |
| 2 |
15 |
19.9 ± 31.4 |
4.8 ± 8.0 |
2.3 ± 3.3 |
| 3 |
30 |
12.2 ± 15.7 |
2.5 ± 4.1 |
1.4 ± 4.1 |
| 4 |
60 |
12.0 ± 17.7 |
3.8 ± 7.1 |
1.0 ± 1.7 |
| 5 |
90 |
0 |
0 |
0 |
| 6 |
120 |
3.1 ± 9.5 |
0.2 ± 0.6 |
0.1 ± 0.3 |
| 7 |
240 |
0 |
0 |
0 |
|
*Number of mice was 10 for each group, except group 5 that had 9 mice. | ||||
Silverstone et al. Annals of General Psychiatry 2008 7:27 doi:10.1186/1744-859X-7-27 |
||||
