Table 5 |
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|
Effect of bupropion HCl 120 mg/kg intraperitoneal infusion times on the mean ± SD intensity of bupropion HCl-induced convulsions in mice |
||||
| Group* |
Intraperitoneal (IP) infusion time (min) |
Mean ± SD intensity of convulsions |
||
|
|
||||
| Mild |
Moderate |
Severe |
||
|
|
||||
| 1 |
0 (bolus) |
10.0 ± 12.9 |
5.5 ± 10.4 |
0 |
| 2 |
15 |
14.2 ± 17.4 |
7.1 ± 10.9 |
5.9 ± 13.1 |
| 3 |
30 |
9.2 ± 11.7 |
4.1 ± 6.4 |
2.8 ± 8.9 |
| 4 |
60 |
10.2 ± 16.4 |
4.6 ± 7.0 |
2.2 ± 4.8 |
| 5 |
90 |
0 |
0 |
0 |
| 6 |
120 |
2.8 ± 8.5 |
0.5 ± 1.6 |
0.1 ± 0.3 |
| 7 |
240 |
0 |
0 |
0 |
|
*Number of mice was 10 for each group, except group 5 that had 9 mice. | ||||
Silverstone et al. Annals of General Psychiatry 2008 7:27 doi:10.1186/1744-859X-7-27 |
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